In the modern age, condoms are most often made from latex, but some are made from other materials such as polyurethane, polyisoprene, or lamb intestine. A female condom is also available, most often made of polyurethane. As a method of contraception, male condoms have the advantage of being inexpensive, easy to use, having few side effects, and of offering protection against sexually transmitted diseases. With proper knowledge and application technique—and use at every act of intercourse—women whose partners use male condoms experience a 2% per-year pregnancy rate.

The rubber vulcanization process was patented by Charles Goodyear in 1844. The first rubber condom was produced in 1855. For many decades, rubber condoms were manufactured by wrapping strips of raw rubber around penis-shaped molds, then dipping the wrapped molds in a chemical solution to cure the rubber. In 1912, a German named Julius Fromm developed a new, improved manufacturing technique for condoms: dipping glass molds into a raw rubber solution. Called cement dipping, this method required adding gasoline or benzene to the rubber to make it liquid. Latex, rubber suspended in water, was invented in 1920. Latex condoms required less labor to produce than cement-dipped rubber condoms, which had to be smoothed by rubbing and trimming. The use of water to suspend the rubber instead of gasoline and benzene eliminated the fire hazard previously associated with all condom factories. Latex condoms also performed better for the consumer: they were stronger and thinner than rubber condoms, and had a shelf life of five years (compared to three months for rubber).

Until the twenties, all condoms were individually hand-dipped by semiskilled workers. Throughout the decade of the 1920s, advances in the automation of the condom assembly line were made. The first fully automated line was patented in 1930. Major condom manufacturers bought or leased conveyor systems, and small manufacturers were driven out of business. The skin condom, now significantly more expensive than the latex variety, became restricted to a niche high-end market.